منابع مشابه
Mechanotransduction: Feeling the Squeeze in the C. elegans Reproductive System
A new study reports that the RhoGAP SPV-1 senses membrane curvature and cell stretch in the Caenorhabditis elegans spermatheca. Without SPV-1, the cells of the spermatheca are hypercontractile, leading to deformation and rapid ejection of the fertilized eggs. The spermatheca may provide a paradigm for understanding how cells detect mechanical stimuli in vivo.
متن کاملFeeling the Squeeze: Live-Cell Extrusion Limits Cell Density in Epithelia
bind both of these cellular targets to enable ferroptosis? Previous studies showed that erastin inhibits VDACmediated transport of NADH into mitochondria, thus raising the possibility that erastin’s effects on VDAC may help to elevate cytosolic levels of NADPH to support the activity of cytosolic oxidases that generate lethal levels of ROS (Yagoda et al., 2007; Yang and Stockwell, 2008). Conseq...
متن کاملThe Economics of Margin Squeeze∗
The paper discusses economic theories of harm for anti-competitive margin squeeze by unregulated and regulated vertically integrated firms. We review both predation and foreclosure theories, as well as the mere exploitation of upstream market power. We show that foreclosure provides an appropriate framework in the case of an unregulated firm, whereas a firm under tight wholesale regulation shou...
متن کاملWhat feeling is the "feeling of knowing?".
Having a word on the tip of our tongue is a mundane and slightly annoying experience. And yet, as Brown’s article helps us see, the theoretical implications of a TOT experience range very widely. The study of TOTs may also turn out to be useful for larger methodological reasons. Here, too, Brown recognizes that the investigation of TOTs offers an especially good example of convergent cognitive ...
متن کاملDead cells get the squeeze
acrophages can clean up the detritus of dying cells. But that, say Jody Rosenblatt, Martin Raff, and Louise Cramer (University College London, London, UK), is not the whole story. They have found that cells undergoing apoptosis in an epithelial sheet signal to their neighbors to begin squeezing, in a process that maintains the barrier function of the epithelium while extruding the dying cell. M...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 2006
ISSN: 0959-8138,1756-1833
DOI: 10.1136/bmj.39044.677280.db